Drug-like Properties

Drug-like Properties
Author : Li Di
Publisher : Academic Press
Total Pages : 580
Release : 2016-01-12
ISBN 10 : 0128010762
ISBN 13 : 9780128010761
Language : EN, FR, DE, ES & NL

Drug-like Properties Book Description:

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization. Provides a comprehensive and valuable working handbook for scientists and students in medicinal chemistry Includes expanded coverage of pharmacokinetics fundamentals and effects Contains updates throughout, including the authors' recent work in the importance of solubility in drug development; new and currently used property methods, with a reduction of seldom-used methods; and exploration of computational modeling methods

Genre
Drug-like Properties
Language: en
Pages: 580
Authors: Li Di
Categories:
Type: BOOK - Published: 2016-01-12 - Publisher: Academic Press

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (ab
Optimizing the
Language: en
Pages: 512
Authors: Ronald Borchardt
Categories: Medical
Type: BOOK - Published: 2007-12-31 - Publisher: Springer Science & Business Media

This book arises from a workshop organized by the American Association of Pharmaceutical Scientists entitled "Optimizing the Drug-Like Properties of Leads in Dr
Drug-Like Properties
Language: en
Pages: 580
Authors: Li Di
Categories: Science
Type: BOOK - Published: 2015-12-17 - Publisher: Academic Press

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (ab
Drug-like Properties: Concepts, Structure Design and Methods
Language: en
Pages: 552
Authors: Li Di
Categories: Science
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Language: en
Pages: 511
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Categories: Medical
Type: BOOK - Published: 2014-10-31 - Publisher: Springer

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Pages: 512
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Pages: 502
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Pages: 474
Authors: Arun K. Ghosh
Categories: Medical
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Drug design is a complex, challenging and innovative research area. Structure-based molecular design has transformed the drug discovery approach in modern medic
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Language: en
Pages: 225
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Language: en
Pages: 314
Authors: Alex Avdeef
Categories: Science
Type: BOOK - Published: 2003-09-19 - Publisher: John Wiley & Sons

Many times drugs work fine when tested outside the body, but when they are tested in the body they fail. One of the major reasons a drug fails is that it cannot