Drug-Like Properties

Drug-Like Properties
Author : Li Di
Publisher : Academic Press
Total Pages : 580
Release : 2015-12-17
ISBN 10 : 9780128013229
ISBN 13 : 0128013222
Language : EN, FR, DE, ES & NL

Drug-Like Properties Book Description:

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization. Provides a comprehensive and valuable working handbook for scientists and students in medicinal chemistry Includes expanded coverage of pharmacokinetics fundamentals and effects Contains updates throughout, including the authors’ recent work in the importance of solubility in drug development; new and currently used property methods, with a reduction of seldom-used methods; and exploration of computational modeling methods

Drug-Like Properties
Language: en
Pages: 580
Authors: Li Di
Categories: Science
Type: BOOK - Published: 2015-12-17 - Publisher: Academic Press

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (ab
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Language: en
Pages: 512
Authors: Ronald Borchardt
Categories: Medical
Type: BOOK - Published: 2007-12-31 - Publisher: Springer Science & Business Media

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Language: en
Pages: 552
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Categories: Science
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Language: en
Pages: 511
Authors: Allen C Templeton
Categories: Medical
Type: BOOK - Published: 2014-10-31 - Publisher: Springer

This authoritative volume provides a contemporary view on the latest research in molecules with optimal drug-like properties. It is a valuable source to access
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Language: en
Pages: 512
Authors: Katya Tsaioun
Categories: Medical
Type: BOOK - Published: 2011-02-15 - Publisher: John Wiley & Sons

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Pages: 474
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Language: en
Pages: 418
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Recent reports of drug attrition rates have revealed that a significant number of drug candidates fail in the later stage of clinical development due to absorpt
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Language: en
Pages: 517
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Categories: Medical
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The number of available synthetic methods can be overwhelming. In order to create novel motifs and templates which confer new and potentially valuable drug-like
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Language: en
Pages: 214
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Categories: Medical
Type: BOOK - Published: 2011-09-07 - Publisher: Springer

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Language: en
Pages: 129
Authors: Chris G. Kruse
Categories: Medical
Type: BOOK - Published: 2008-01-01 - Publisher: IOS Press

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