WEBER-COCKAYNE SYNDROME - This represents a group of rare inherited disorders in which blistering of the skin occurs in response to skin trauma. Large fluid-filled blisters can occur in response to injury, skin rubbing, chafing, or even increases in room temperature. Secondary bacterial infection of the blisters is common. Complications include esophageal stricture, infections, loss of function of hands and feet, and malnutrition. The dermatologist is the expert in the evaluation and treatment of this disorder.