HEMOGLOBIN SC DISEASE - A rare genetic disease of the hemoglobin. Consists of two abnormal hemoglobins: s and c. Estimated prevalence to be 0.04 to .13% in the African American population. Patients are anemic due to the premature breakdown of the blood cells in the spleen. Produces a sickle cell-like syndrome. Jaundice may be seen in some patients. Complications include thromboembolic disease, renal papillary necrosis, aseptic necrosis of the femoral (and humeral) head, increased rates of early spontaneous abortion (in pregnant women with SC disease), and proliferative retinopathy. There is no specific treatment other than supportive care.