GASTRIC ULCER - An ulcer in the mucosal lining of the stomach. Ulcer formation results from gastric inflammation that may be triggered by the use of alcohol, aspirin, or nonsteroidal anti-inflammatories agents. Symptoms include recurrent abdominal pains (may be relieved by antacids), nausea, vomiting, weight loss, and fatigue. Complications include GI bleeding, obstruction, perforation, and ulcer penetration into surrounding tissues. Treatment includes the avoidance of alcohol, smoking, aspirin, anti-inflammatories, and caffeine. Medications such as antacids or H2 antagonists (e.g. cimetidine, ranitidine) or proton pump inhibitors (omeprazole) have been shown to be effective treatment.