BAMBERGER-MARIE SYNDROME - A condition which describes the broadening or thickening of the tips of the fingers (and toes) with increased lengthwise curvature of the nail and a decrease in the angle normally seen between the cuticle and the fingernail. Changes may also occur in the long bones and the joints. Affected individuals may complain of pain and swelling in the wrists and ankles. Often this finding on physical examination can be quite subtle and easily overlooked. Clubbing may be seen in a wide variety of conditions---most of which result in a decrease in blood oxygen. Examples include: tetralogy of Fallot, transposition of the great vessels, atrial myxomas, cystic fibrosis, emphysema, lung cancer (bronchogenic carcinoma), tuberculosis, cystic fibrosis, asbestosis, bronchiectasis, Hodgkin's disease, cirrhosis, chronic active hepatitis, and Crohn's disease. This finding will generally provoke a more detailed patient evaluation.